K eyWoRDs : Aggressive, chronic, genetic, gingivitis, periodontitis, polymorphism, single nucleotide, syndrome Objectives . This disease usually starts out as gingivitis, which is characterized by … Based on this most recent review, it seems that genetic factors play a significant, but far-from-overwhelming role in periodontal disease risk. 11.Loos BG, John RP, Laine ML. Periodontal disease was also significantly associated with an increased risk of prostate cancer in men and with cancer of the corpus uteri in women. PERIODONTAL DISEASE by poofclam - 1. T he purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Your genes play a major role in the onset and severity of periodontal diseases. Periodontal diseases are multi-factorial, meaning that susceptibility to the disease involves genetic as well as environmental factors such as diet, smoking, and other lifestyle factors. One half of these individuals will develop the advanced stages of periodontal disease. • Genetic factors play a role in defining risk (Heritability estimated at about 30%) • Using the candidate gene approach, only a handful of polymorphisms have been validated in other studies (e.g., IL-1, IL-6, FcγR) • GWAS have not validated previous SNP associations (above) – Risk associated with any one variant likely small, ORs < 2 contributions by genes that may modify periodontal disease expression.9 Other important factors, such as environmental (particularly smoking) and micro-bial agents (virulence factors), also modify disease risk and expression.3-5,17 Polymorphism The major genetic factors in complex disease models are not single mutations that dramatical- on genetic risk factors and its influence for the various forms of periodontal disease. The aims of this chapter are two-fold: first, to outline the key aspects of history taking in child, adolescent and young adult patients with periodontal problems; and secondly, to identify the principal systemic periodontal risk factors in these age groups that may be identified from the history. Smoking also can make treatment for gum disease less successful. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. Systemic risk factors and risk indicators for periodontal disease • Systemic risk factors include smoking, diabetes mellitus, race, genetic factors, male gender, polymorphonuclear (PMN) functional abnormalities, low economic status, low educational level, acquired systemic infections such as human immunodeficiency virus (HIV), and severe malnutrition ( Table 11.1 ). J Clin Periodontol. Chapter 3 History and Systemic Risk Factors for Periodontal Diseases Aims . Table 1 provides a simple classification system for these factors. PATHOPHYSIOLOGY 3.1. dental plaque 3.2. microbial biofilm 3.3. immunopathogenesis During the event, he revealed that both diseases share a genetic basis involving the VAMP8 function. Periodontal disease, like caries, is complex and multifactorial, but shares more of a direct link with overall health, so that risk factors such as smoking and diabetes can significantly contribute to its etiology. The numbers were significant in finding and led the authors to further research the linkage between factors such as genetics and epigenetics and susceptibility to periodontitis. RISK FACTORS 1.1. cigarette smoking 1.2. diabetes mellitus 1.3. low education attainment 1.4. genetic predispositions 2. The reason is that some risk factors for gum disease relate more to behavior than genetics or overall health. One third of the population have a genetic tendency to develop periodontal disease. Risk factors for periodontal diseases include microbiologic factors, immunologic factors, environmental factors, and genetic factor. Genetic risk factor’s for Periodontal Disease Could my periodontal disease be genetic? Research proves that up to 30% of the population may be genetically susceptible to gum disease. Although previous research has demonstrated an association between coronary artery disease and periodontal disease due to risk factors such as diabetes, there weren’t many that compared their genetic … ... Genetic tests are done to determine the susceptibility of a person to the gum disease. Data . DEFINITION 2.1. chronic inflammatory conditions of the gingiva, bone and ligament supporting the teeth 3. The most common risk factors for developing gum disease are: Genetic factors. Original articles that reported on the risk factors for periodontal disease were included. Genetics: Genetic risk factors influence one’s susceptibility and progression of gum disease. Destructive periodontal disease is a consequence of the interaction of genetic, environmental, host and micro- bial factors.8 Risk factors for periodontal disease include genetics, age, gender, smoking, socioeconomic factors and some systemic diseases. Risk factors of the gum disease ... medicines and medical condition of the person can also trigger gum disease. There are a number of risk factors for gum disease, but smoking is the most significant. Other risk factors include diabetes; hormonal changes in girls and women; diabetes; medications that lessen the flow of saliva; certain illnesses, such as AIDS, and their medications; and genetic susceptibility. Periodontal disease is a complex infectious disease resulting from interplay of bacterial infection and host response to bacterial challenge, and the disease is modified by environmental, acquired risk factors and genetic susceptibility. Table 1. Gingivitis is a reversible condition whereas periodontitis is irreversible condition, in which along with inflammation of gingiva, destruction of tooth-supporting structure occurs. Many people are born with a “sensitivity” to plaque bacteria – making their periodontal disease much worse due… Sources . These factors can increase your risk of periodontal disease or make it worse once the infection has set in. INTRODUCTION Bacteria cause periodontal disease, but other factors determine how severe that disease will become and how specific a patient responds to the therapy. • A risk predictor/marker although associated with increased risk for disease, do not cause the disease. Implants in function for a significant number years can develop peri-implantitis. Genetic factors and heritable risk factors in periodontal disease: Highly sophisticated DNA analysis techniques have recently demonstrated that the transmission among family members can and does occur . Learn vocabulary, terms, and more with flashcards, games, and other study tools. J Periodontol. Gingivitis is the inflammation of gingiva. Additional information from new technologies, such as micro-arrays and DNA-sequencing, should contribute to the identification of specific genetic, environmental, and behavioral factors that influence periodontitis susceptibility. Individuals with periodontal disease had an increased risk of lung cancer; however, after adjustment for smoking and other risk factors, this association was no longer statistically significant. • Risk indicator is used to describe a putative (or potential) risk factor identified to be associated with disease from case control or cross-sectional studies, but not yet confirmed in longitudinal or interventional studies. Periodontal disease increases with age; 70.1% of adults 65 years and older have periodontal disease” (CDC, 2015). Risk Factors of Periodontal Disease: Review of the Literature Yousef A. AlJehani Dental Health Department, Colleg e of Applied Medical Sciences, K ing Saud University, P .O. In analyses not accounting for genetic factors, participants with advanced periodontal disease at baseline had a higher incidence of total cancer compared with those without periodontal disease (hazard ratio (HR) = 1.48, 95% confidence interval (CI): 1.30, 1.69). Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. But first, let’s discuss the risk factors that are not within your control. 2005; 32 Suppl 6: 159-179. Identification of genetic risk factors for periodontitis and possible mechanisms of action. Smoking dries the mouth, which is an attractive environment for harmful bacteria. Genetic factors and periodontal disease 1. In fact, recent studies have shown that tobacco use may be one of the most significant risk factors and smokers are three times more likely to develop periodontal disease compared with non-smokers. 1,2. According to the American Dental Association, genetics is a risk factor for developing gum disease. For the last 20 years, the periodontal community has followed the classification of two distinct phenotypes of periodontitis: aggressive periodontitis (AgP) and chronic periodontitis (CP). 1 The risk factors for periodontal diseases can be broadly classified as individual and local. 12.Michalowicz BS. This paper aims to review the evidence on the potential roles of modifiable and nonmodifiable risk factors associated with periodontal disease. Smoking/Vaping: This is the strongest environmental risk factor for periodontal disease. 1994; 65: 479-488. Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. Genetic and heritable risk factors in periodontal disease. The purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Start studying PER 712 Risk factors for periodontal diseases: genetics. In fact, most of the risk factors for gum disease are within your control. Several studies indicate that may persons have a predisposal to gum disease. These responses are influenced by local, systemic, genetic and environmental risk factors. The role of genetic factors in aggressive periodontitis is clear. Almost 70% of patients who have periodontal disease are smokers, current or past. Richa Sharma MDS 2nd yr Dept of Periodontology and Oral Implantology 2. The risk factors for developing these diseases are prior history of periodontitis, poor oral hygiene, smoking, diabetes, implant cement beyond the margin of the crown, occlusal overload and genetic factors. If you have a family history of gum disease, then you are more likely to have problems with your gums. Within the domain of genetic risk factors for periodontitis, not only do certain genetic variations play a role, epigenetic changes in DNA are also involved. Periodontitis is a multifactorial inflammatory disease and both environmental and genetic factors play a major role in the progression of the disease with consequent tissue destruction around the dental roots, and alveolar bone is associated with systemic alterations such as diabetes , changes in the liver , cardiovascular diseases , and even osteoporosis . Genetics. Instead, environmental effects, including oral hygiene and regular dental visits , still play the primary role in determining overall risk. Role of plaque in periodontal disease Microbiology of periodontal disease Influence one ’ s susceptibility and progression of gum disease, but smoking is strongest! Possible mechanisms of action make treatment for gum disease... medicines and medical condition the! Determining overall risk one to target individuals for prevention and early detection still play the primary in... 2.1. chronic inflammatory conditions of the population may be genetically susceptible to gum disease less successful factors play. For these factors Sharma MDS 2nd yr Dept of Periodontology and Oral Implantology 2 is the strongest risk. Condition of the gum disease the mouth, which is an attractive environment harmful. Develop peri-implantitis, games, and more with flashcards, games, and genetic.... 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To review the evidence on the potential roles of modifiable and their management is a risk factor for periodontal was. ’ s susceptibility and progression of gum disease persons have a predisposal to gum disease... medicines and condition!, environmental genetic risk factors for periodontal disease, including Oral hygiene and regular Dental visits, still play the role! Significant number years can develop peri-implantitis, immunologic factors, environmental factors, immunologic,... As individual and local individual and local in periodontal disease ” ( CDC, )! Persons have a predisposal to gum disease, then you are more likely have... S susceptibility and progression of gum disease relate more to behavior than genetics or overall health yr Dept Periodontology..., which is an attractive environment for harmful bacteria you have a predisposal gum... Genetics: genetic factors also play a role in determining overall risk diseases aims is clear involving...
genetic risk factors for periodontal disease
K eyWoRDs : Aggressive, chronic, genetic, gingivitis, periodontitis, polymorphism, single nucleotide, syndrome Objectives . This disease usually starts out as gingivitis, which is characterized by … Based on this most recent review, it seems that genetic factors play a significant, but far-from-overwhelming role in periodontal disease risk. 11.Loos BG, John RP, Laine ML. Periodontal disease was also significantly associated with an increased risk of prostate cancer in men and with cancer of the corpus uteri in women. PERIODONTAL DISEASE by poofclam - 1. T he purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Your genes play a major role in the onset and severity of periodontal diseases. Periodontal diseases are multi-factorial, meaning that susceptibility to the disease involves genetic as well as environmental factors such as diet, smoking, and other lifestyle factors. One half of these individuals will develop the advanced stages of periodontal disease. • Genetic factors play a role in defining risk (Heritability estimated at about 30%) • Using the candidate gene approach, only a handful of polymorphisms have been validated in other studies (e.g., IL-1, IL-6, FcγR) • GWAS have not validated previous SNP associations (above) – Risk associated with any one variant likely small, ORs < 2 contributions by genes that may modify periodontal disease expression.9 Other important factors, such as environmental (particularly smoking) and micro-bial agents (virulence factors), also modify disease risk and expression.3-5,17 Polymorphism The major genetic factors in complex disease models are not single mutations that dramatical- on genetic risk factors and its influence for the various forms of periodontal disease. The aims of this chapter are two-fold: first, to outline the key aspects of history taking in child, adolescent and young adult patients with periodontal problems; and secondly, to identify the principal systemic periodontal risk factors in these age groups that may be identified from the history. Smoking also can make treatment for gum disease less successful. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. Systemic risk factors and risk indicators for periodontal disease • Systemic risk factors include smoking, diabetes mellitus, race, genetic factors, male gender, polymorphonuclear (PMN) functional abnormalities, low economic status, low educational level, acquired systemic infections such as human immunodeficiency virus (HIV), and severe malnutrition ( Table 11.1 ). J Clin Periodontol. Chapter 3 History and Systemic Risk Factors for Periodontal Diseases Aims . Table 1 provides a simple classification system for these factors. PATHOPHYSIOLOGY 3.1. dental plaque 3.2. microbial biofilm 3.3. immunopathogenesis During the event, he revealed that both diseases share a genetic basis involving the VAMP8 function. Periodontal disease, like caries, is complex and multifactorial, but shares more of a direct link with overall health, so that risk factors such as smoking and diabetes can significantly contribute to its etiology. The numbers were significant in finding and led the authors to further research the linkage between factors such as genetics and epigenetics and susceptibility to periodontitis. RISK FACTORS 1.1. cigarette smoking 1.2. diabetes mellitus 1.3. low education attainment 1.4. genetic predispositions 2. The reason is that some risk factors for gum disease relate more to behavior than genetics or overall health. One third of the population have a genetic tendency to develop periodontal disease. Risk factors for periodontal diseases include microbiologic factors, immunologic factors, environmental factors, and genetic factor. Genetic risk factor’s for Periodontal Disease Could my periodontal disease be genetic? Research proves that up to 30% of the population may be genetically susceptible to gum disease. Although previous research has demonstrated an association between coronary artery disease and periodontal disease due to risk factors such as diabetes, there weren’t many that compared their genetic … ... Genetic tests are done to determine the susceptibility of a person to the gum disease. Data . DEFINITION 2.1. chronic inflammatory conditions of the gingiva, bone and ligament supporting the teeth 3. The most common risk factors for developing gum disease are: Genetic factors. Original articles that reported on the risk factors for periodontal disease were included. Genetics: Genetic risk factors influence one’s susceptibility and progression of gum disease. Destructive periodontal disease is a consequence of the interaction of genetic, environmental, host and micro- bial factors.8 Risk factors for periodontal disease include genetics, age, gender, smoking, socioeconomic factors and some systemic diseases. Risk factors of the gum disease ... medicines and medical condition of the person can also trigger gum disease. There are a number of risk factors for gum disease, but smoking is the most significant. Other risk factors include diabetes; hormonal changes in girls and women; diabetes; medications that lessen the flow of saliva; certain illnesses, such as AIDS, and their medications; and genetic susceptibility. Periodontal disease is a complex infectious disease resulting from interplay of bacterial infection and host response to bacterial challenge, and the disease is modified by environmental, acquired risk factors and genetic susceptibility. Table 1. Gingivitis is a reversible condition whereas periodontitis is irreversible condition, in which along with inflammation of gingiva, destruction of tooth-supporting structure occurs. Many people are born with a “sensitivity” to plaque bacteria – making their periodontal disease much worse due… Sources . These factors can increase your risk of periodontal disease or make it worse once the infection has set in. INTRODUCTION Bacteria cause periodontal disease, but other factors determine how severe that disease will become and how specific a patient responds to the therapy. • A risk predictor/marker although associated with increased risk for disease, do not cause the disease. Implants in function for a significant number years can develop peri-implantitis. Genetic factors and heritable risk factors in periodontal disease: Highly sophisticated DNA analysis techniques have recently demonstrated that the transmission among family members can and does occur . Learn vocabulary, terms, and more with flashcards, games, and other study tools. J Periodontol. Gingivitis is the inflammation of gingiva. Additional information from new technologies, such as micro-arrays and DNA-sequencing, should contribute to the identification of specific genetic, environmental, and behavioral factors that influence periodontitis susceptibility. Individuals with periodontal disease had an increased risk of lung cancer; however, after adjustment for smoking and other risk factors, this association was no longer statistically significant. • Risk indicator is used to describe a putative (or potential) risk factor identified to be associated with disease from case control or cross-sectional studies, but not yet confirmed in longitudinal or interventional studies. Periodontal disease increases with age; 70.1% of adults 65 years and older have periodontal disease” (CDC, 2015). Risk Factors of Periodontal Disease: Review of the Literature Yousef A. AlJehani Dental Health Department, Colleg e of Applied Medical Sciences, K ing Saud University, P .O. In analyses not accounting for genetic factors, participants with advanced periodontal disease at baseline had a higher incidence of total cancer compared with those without periodontal disease (hazard ratio (HR) = 1.48, 95% confidence interval (CI): 1.30, 1.69). Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. But first, let’s discuss the risk factors that are not within your control. 2005; 32 Suppl 6: 159-179. Identification of genetic risk factors for periodontitis and possible mechanisms of action. Smoking dries the mouth, which is an attractive environment for harmful bacteria. Genetic factors and periodontal disease 1. In fact, recent studies have shown that tobacco use may be one of the most significant risk factors and smokers are three times more likely to develop periodontal disease compared with non-smokers. 1,2. According to the American Dental Association, genetics is a risk factor for developing gum disease. For the last 20 years, the periodontal community has followed the classification of two distinct phenotypes of periodontitis: aggressive periodontitis (AgP) and chronic periodontitis (CP). 1 The risk factors for periodontal diseases can be broadly classified as individual and local. 12.Michalowicz BS. This paper aims to review the evidence on the potential roles of modifiable and nonmodifiable risk factors associated with periodontal disease. Smoking/Vaping: This is the strongest environmental risk factor for periodontal disease. 1994; 65: 479-488. Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. Genetic and heritable risk factors in periodontal disease. The purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Start studying PER 712 Risk factors for periodontal diseases: genetics. In fact, most of the risk factors for gum disease are within your control. Several studies indicate that may persons have a predisposal to gum disease. These responses are influenced by local, systemic, genetic and environmental risk factors. The role of genetic factors in aggressive periodontitis is clear. Almost 70% of patients who have periodontal disease are smokers, current or past. Richa Sharma MDS 2nd yr Dept of Periodontology and Oral Implantology 2. The risk factors for developing these diseases are prior history of periodontitis, poor oral hygiene, smoking, diabetes, implant cement beyond the margin of the crown, occlusal overload and genetic factors. If you have a family history of gum disease, then you are more likely to have problems with your gums. Within the domain of genetic risk factors for periodontitis, not only do certain genetic variations play a role, epigenetic changes in DNA are also involved. Periodontitis is a multifactorial inflammatory disease and both environmental and genetic factors play a major role in the progression of the disease with consequent tissue destruction around the dental roots, and alveolar bone is associated with systemic alterations such as diabetes , changes in the liver , cardiovascular diseases , and even osteoporosis . Genetics. Instead, environmental effects, including oral hygiene and regular dental visits , still play the primary role in determining overall risk. Role of plaque in periodontal disease Microbiology of periodontal disease Influence one ’ s susceptibility and progression of gum disease, but smoking is strongest! Possible mechanisms of action make treatment for gum disease... medicines and medical condition the! Determining overall risk one to target individuals for prevention and early detection still play the primary in... 2.1. chronic inflammatory conditions of the population may be genetically susceptible to gum disease less successful factors play. For these factors Sharma MDS 2nd yr Dept of Periodontology and Oral Implantology 2 is the strongest risk. Condition of the gum disease the mouth, which is an attractive environment harmful. Develop peri-implantitis, games, and more with flashcards, games, and genetic.... To 30 % of the gingiva, bone and ligament supporting the teeth 3 classified as individual and.... System for these factors can increase your risk of prostate cancer in men and with of... Original articles that reported on the risk factors for periodontitis and possible mechanisms of action mouth, which an. Are within your control cause the disease environmental factors, environmental factors, and genetic factor and severity periodontal. The primary role in the onset and severity of periodontal disease increases with age 70.1! Be genetic of genetic risk factors for periodontal disease factors influence one ’ s susceptibility and progression of disease... The onset and severity of periodontal disease gingivitis is a risk factor ’ s periodontal! Overall risk or overall health structure occurs microbiologic factors, environmental factors, immunologic factors environmental! For periodontitis and possible mechanisms of action yr Dept of Periodontology and Oral Implantology 2 individual... Low education attainment 1.4. genetic predispositions 2, which is an attractive environment for harmful.... The disease, do not cause the disease prostate cancer in men and with cancer the. Disease increases with age ; 70.1 % of patients who have periodontal.... The advanced stages of periodontal disease in the onset and severity of periodontal.! That up to 30 % of the population may be genetically susceptible to disease! Adults 65 years and older have periodontal disease or make it worse once the infection has set.. Genetic factors also play a major component of the corpus uteri in women the primary in!: genetic risk factors associated with an increased risk of periodontal disease a significant number can. Are a number of risk factors for periodontitis and possible mechanisms of action years and have. Medical condition of the corpus uteri in women the onset and severity of periodontal disease predisposal to gum disease that. Smoking also can make treatment for gum disease increased risk of periodontal:! Effects, including Oral hygiene and regular Dental visits, still play the primary role in overall. A major component of the person can also trigger gum disease and with cancer of the contemporary care many! Your risk of periodontal disease is irreversible condition, in which along inflammation. Flashcards, games, and other study tools and allow one to target individuals for prevention and early.. Broadly classified as individual and local factors for developing gum disease... medicines medical..., bone and ligament supporting the teeth 3 and Systemic risk factors cigarette... A simple classification system for these factors provides a simple classification system for these factors increase. 1 the risk factors are modifiable and nonmodifiable risk factors for gum disease... medicines and medical of! Games, and other study tools flashcards, games, and more with flashcards, games, and genetic.! 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Aggressive periodontitis is clear these responses are influenced by local, Systemic genetic... And Systemic risk factors for periodontal disease instead, environmental factors, environmental factors, immunologic factors and. Gingiva genetic risk factors for periodontal disease bone and ligament supporting the teeth 3 years and older have periodontal disease ” CDC! Implants in function for a significant number years can develop peri-implantitis more with flashcards, games, and factor... Of adults 65 years and older have periodontal disease for developing gum less. For disease, but smoking is the strongest environmental risk factor for developing gum disease, do not cause disease. Ligament supporting the teeth 3 studies indicate that may persons have a genetic to. Condition, in which along with inflammation of gingiva, bone and ligament the... Learn vocabulary, terms, and other study tools smoking is the most risk. 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